Nuclear m 6 A Reader YTHDC1 Regulates mRNA Splicing

Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing.

N(6)-Methyladenosine (m(6)A) is emerging as a chemical mark that broadly affects the flow of genetic information in various biological processes in eukaryotes. Recently, Xiao et al. reported that the nuclear m(6)A reader protein YTHDC1 impacts mRNA splicing, providing a transcriptome-wide glance of splicing changes affected by this mRNA methylation reader protein.

Nuclear mA Reader YTHDC1 Regulates mRNA Splicing

RNAcatalyses nuclear pre-mRNA splicing

In nuclear pre-messenger RNA splicing, introns are excised by the spliceosome, a dynamic machine composed of both proteins and small nuclear RNAs (snRNAs). Over thirty years ago, after the discovery of self-splicing group II intron RNAs, the snRNAswere proposed to catalyse splicing. However, no definitive evidence for a role of either RNAor protein in catalysis by the spliceosome has been repor...

TRAP150 activates pre-mRNA splicing and promotes nuclear mRNA degradation

TRAP150 has been identified as a subunit of the transcription regulatory complex TRAP/Mediator, and also a component of the spliceosome. The exact function of TRAP150, however, remains unclear. We recently identified TRAP150 by its association with the mRNA export factor TAP. TRAP150 contains an arginine/serine-rich domain and has sequence similarity with the cell death-promoting transcriptiona...

Corrigendum: Structural basis for selective binding of m(6)A RNA by the YTHDC1 YTH domain.

Nat. Chem. Biol. 10, 927–929 (2014); published online 21 September 2014; corrected after print 19 August 2015 In the version of this Brief Communication initially published, the email address for corresponding author, Chao Xu, was incorrect. It should be listed as [email protected]. This error has been corrected in the PDF and HTML versions of the article. CORRIGENDUM Structural basis of en...